- Directly targets the cause of disease
- Treatment without steroids
- Effectively reduce skin allergy symptoms.
- Provides relief from itchy skin and rash
- FDA approved
Treatment of chronic manifestations of atopic dermatitis in dogs.
Possible Side Effects:
In rare cases, vomiting and diarrhea were the most common adverse reactions.
Gingival hyperplasia and papillomas may also occur during the initial dosing phase.
ATOPICA (cyclosporine) is a potent systemic immunosuppressant that may increase the susceptibility to infection and the development of neoplasia.
Notify your veterinarian immediately if your pet develops fever (over 103°), painful urination, tiredness, sneezing, coughing, or runny nose. These symptoms could be early signs of dangerous side effects.
ATOPICA should be stored and dispensed in the original unit-dose container at controlled room temperature between 59° and 77°F (15-25°C).
Dosage and Administration
The mean recommended dose rate of cyclosporin is 5 mg/kg body weight per day given according to the following scheme.
Body weight of the dog kg Number of capsules given to obtain the recommended dose
|Body weight of the dog kg
||Number of capsules given to obtain the recommended dose
|2 to <3
||1 x 10mg
|3 to <4
||2 x 10mg
|4 to <7.5
||1 x 25mg
|7.5 to < 15
||1 x 50mg
|15 to <29
||1 x 100mg or 2 x50 mg
|29 to <36
||3 x 50mg
||2 x 100mg
ATOPICA will initially be given daily until a satisfactory clinical improvement is seen. This will generally be the case after 4 to 8 weeks. If no response is obtained within the first 8 weeks, the treatment should be stopped. Once the clinical signs of atopic dermatitis are satisfactorily controlled, ATOPICA can be given every second day. If the signs are then controlled with this dosing, ATOPICA can be then given every 3 to 4 days. The veterinary surgeon will adjust the frequency of administration to the response. Treatment may be stopped when the clinical signs are controlled. Upon recurrence of clinical signs, treatment should be resumed at daily dosing, and in certain cases repeated treatment courses may be required. Treatments of up to several months have been shown to be well tolerated. ATOPICA should be given at least 2 hours before or after feeding. Insert the capsule directly into the dog's mouth.
Soft capsule of 4 strenghts are available:
ATOPICA contains 10 mg, 25 mg, 50 mg or 100 mg Cyclosporine A per capsule.
Tocopherol E-307, iron oxide black E 172, titanium dioxide E 171, Carminic acid, excip. ad sol..
PropertiesATOPICA contains Cyclosporine A ATCvet code QL04A A01 a selective immunosuppressor. It is a cyclic polypeptide consisting of 11 amino acids with a molecular weight of 1203 Daltons which acts specifically and reversibly on T-lymphocytes. Cyclosporine has anti-inflammatory and anti-pruritic activities in atopic dermatitis. Cyclosporine acts specifically and reversibly on T-lymphocytes and inhibits the antigen-triggered release of lymphokines by activated T-cells. It also inhibits eosinophil recruitment and activation, keratinocyte cytokine production, Langerhans' cell functions, degranulation of mastocytes and therefore release of histamine and pro inflammatory cytokines. Cyclosporine does not depress hemopoiesis and has no effect on the function of phagocytic cells.