- non-narcotic sedative and analgesic
- for use in horses.
- it has been used successfully to calm fractious horses, to provide relief from abdominal pain and to facilitate medical procedures.
- Dormosedan is given IV or IM, depending upon application.
Possible Side Effects:
Horses treated with Dormosedan® exhibit hypertension. Bradycardia routinely occurs 1 minute after injection. The relationship between hypertension and bradycardia is consistent with an adaptive baroreceptor response to the increased pressure and inconsistent with a primary drug-induced bradycardia. Piloerection, sweating, salivation, and slight muscle tremors are frequently seen after administration. Partial transient penis prolapse may be seen. Partial AV and SA blocks may occur with decreased heart and respiratory rates. Urination typically occurs during recovery at about 45-60 minutes posttreatment, depending on dosage. Incoordination or staggering is usually seen only during the first 3-5 minutes after injection, until animals have secured a firm footing.
Because of continued lowering of the head during sedation, mucus discharges from the nose and, occasionally, edema of the head and face may be seen. Holding the head in a slightly elevated position generally prevents these effects.
Not for use in horses intended for food. Not for human use. Keep out of reach of children
Store at controlled room temperature 15°-30°C (59°-86°F) in the absence of light.
DOSAGE AND ADMINISTRATION:
It is important to follow your Veterinarian's prescription instructions for your horse
For Sedation: Administer Dormosedan IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight 0.2 or 0.4 mL of Dormosedan® per 100 kg or 220 lb, depending on the depth and duration of sedation required. Onset of sedative effects should be reached within 2-4 minutes after IV administration and 3-5 minutes after IM administration. Twenty mcg/kg will provide 30-90 minutes of sedation and 40 mcg/kg will provide approximately 90 minutes to 2 hours of sedation.
For Analgesia: Administer Dormosedan IV at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight 0.2 or 0.4 mL of Dormosedan® per 100 kg or 220 lb, depending on the depth and duration of analgesia required. Twenty mcg/kg will usually begin to take effect in 2-4 minutes and provide 30-45 minutes of analgesia. The 40 mcg/kg dose will also begin to take effect in 2-4 minutes and provide 45-75 minutes of analgesia.
For Both Sedation and Analgesia: Administer Dormosedan® IV at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight 0.2 or 0.4 mL of Dormosedan® per 100 kg or 220 lb, depending on the depth and duration of sedation and analgesia required.
Before and after injection, the animal should be allowed to rest quietly.
Dormosedan (detomidine hydrochloride) Gel is a synthetic alpha2-adrenoreceptor agonist that is indicated for sedation and restraint in horses only. It produces sedation when administered sublingually at 0.018 mg/lb (0.040 mg/kg). It must be placed beneath the tongue of the horse and is not meant to be swallowed. Impermeable gloves must be used during drug administration and during procedures that require contact with the horse’s mouth.
Detomidine hydrochloride is tolerated in horses at up to 200 mcg/kg of body weight 10 times the low dosage and 5 times the high dosage. In safety studies in horses, detomidine hydrochloride at 400 mcg/kg of body weight administered daily for 3 consecutive days produced microscopic foci of myocardial necrosis in 1 of 8 horses.