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  • Marquis Oral Paste Marquis Oral Paste
  • Marquis Oral Paste Marquis Oral Paste

Marquis Oral Paste

by Merial

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This product requires a veterinarian's prescription.

This Rx product can not be shipped to some states.



  • Marquis 15% w/w ponazuril Antiprotozoal Oral Paste offers proven efficacy against equine protozoal myeloencephalitis EPM
  • Ponazuril acts against the parasite at several stages of the lifecycle
  • Ponazuril crosses the blood/brain barrier to reach the central nervous system CNS where it kills the parasite.
  • Formulated in a low-volume paste that horses readily accept.
  • Administered once a day for 28 days.
  • Simple, low-dose regimen 
  • Packaged with four syringe barrels and four reusable plungers with a calibrated dosing ring. Each syringe barrel contains enough ponazuril to treat one 1,200-pound horse for seven days.

 Possible Side Effects:

Blisters on the nose and mouth, skin rash or hives for up to 18 days, loose stools throughout the treatment period, mild colic and seizures have been observed in some case of horses treated with Marquis.


keep out of reach of children and pets.

The safe use of this product in horses used for breeding purposes, during pregnancy or in lactating mares, has not been evaluated.


Store at Controlled Room Temperature 15-30° C (59-86° F).





It is important to follow your Veterinarian's prescription instructions and dosage for your pet.

Administer MARQUIS at a dose of 15 mg/kg (6.81 mg/lb) body weight as a loading dose for the first dose only. The loading dose is followed by a maintenance dose of 5 mg/kg (2.27 mg/lb) body weight once daily for a period of 27 additional days.

DAY 1: Administer a loading dose of 15 mg/kg (three times the maintenance dose) once by mouth. Because the dosage ring is calibrated by weight for the maintenance dose (5 mg/kg), adjust the dosage ring to the appropriate weight and administer this 5 mg/kg dose orally, three consecutive times for a total dose of 15 mg/kg.

DAY 2 through 28: Administer the maintenance dose of 5 mg/kg once daily by mouth.


Paste syringe assembly:

Before administration, the syringe barrel and plunger require assembly. Ensure plunger is clean and dry.

Step 1. End cap must be on syringe barrel when inserting plunger.

Step 2. Carefully insert reusable plunger into base of syringe barrel until it snaps into place, then remove end cap and gently apply pressure to the plunger until paste is seen at the tip of the syringe barrel.

Step 3. Return end cap to tip of paste syringe.

Administering MARQUIS to the horse:

NOTE: The paste syringe is a multi-dose package. Ensure that the correct dose is administered with each use. For the first dose only, complete steps 3 through 6 three times, then continue with steps 7 and 8.

Step 1. Remove end cap and gently apply pressure to the plunger until paste is seen at the tip of the syringe barrel. Return end cap to tip of paste syringe.

Step 2. Determine weight of horse and ensure the horse’s mouth contains no feed.

Step 3. To measure dose, dosage ring collar and barrel collar should be flush. Hold plunger and rotate dosage ring with the other hand to the weight of the horse.

Step 4. Remove end cap from tip of syringe barrel.

Step 5. The selected dose of paste should be deposited onto the back and top of the horse’s tongue. Introduce tip of paste syringe into the side of the horse’s mouth at the space between the front (incisor) and back (molar) teeth. Deposit paste on the horse’s tongue by depressing the plunger of the syringe as far as the dose ring permits. Remove tip of syringe from horse’s mouth.

Step 6. To aid swallowing of paste, immediately raise horse’s head for a few seconds after dosing.

Step 7. Clean the tip of the syringe with a clean disposable towel and return end cap to tip of syringe barrel.

Step 8. For the next daily dose, repeat steps 1-7.

NOTE: At the end of the prescribed treatment period, partially used syringes should be discarded.


Each gram of paste contains 150 mg of ponazuril (15% w/w). MARQUIS is designed to be delivered as an orally administered paste.

Each syringe barrel of MARQUIS contains enough paste to treat one (1) 1,200 lb (544 kg) horse for seven (7) days, at a dose rate of 5 mg/kg (2.27 mg/lb) body weight or to treat one 1,200 lb (544 kg) horse with a single loading dose of 15 mg/kg (6.81 mg/lb) body weight and for four days subsequently at a rate of 5 mg/kg (2.27 mg/lb) body weight. 

Additional Information

Is Rx Product Yes

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