Details
BENEFITS:
- FDA-approved for treating canine bacterial skin infections
- Simple once-a-day dosing
- Comes in a film-coated tablet for easy administration
- Can be given with or without food
CONTRAINDICATIONS:
Cefpodoxime proxetil is contraindicated in dogs with known allergy to cefpodoxime or to the &beta-lactam penicillins and cephalosporins group of antibiotics.
WARNINGS:
Not for human use. Keep this and all drugs out of reach of children. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.
PRECAUTIONS:
The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs 'test.
POSSIBLE SIDE EFFECTS:
Stop giving Cefpodoxime Proxetil or Simplicef and seek emergency veterinary medical care in the event of an allergic reaction shortness of breath hives swelling of the lips, tongue, or face rash or fainting, severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur.  Continue to give Simplicef and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
POSSIBLE DRUG INTERACTIONS:
Before giving Cefpodoxime Proxetil or Simplicef, tell your veterinarian if your pet is being given another antibiotic for the same or a different infection, probenecid, a loop diuretic such as furosemide, or warfarin. You may need to have the dosage adjusted. Drugs other than those listed here may also interact with Cefpodoxime Proxetil or Simplicef. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
Instructions
DOSAGE AND ADMINISTRATION:
It is important to follow your Veterinarian's prescription instructions for your pet.
The dose range of Cefpodoxime Proxetil or SIMPLICEF tablets is 5-10 mg/kg 2.3-4.5 mg/lb body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient's host-defense mechanisms. 
Cefpodoxime Proxetil or SIMPLICEF tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections should not be continued for more than 3-4 days if no response to therapy is seen.
