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  • Heartgard Plus for Dogs Heartgard Plus for Dogs
  • Heartgard Plus for Dogs Heartgard Plus for Dogs
  • Heartgard Plus for Dogs Heartgard Plus for Dogs
  • Heartgard Plus for Dogs Heartgard Plus for Dogs

Trifexis Chewable Tablets for Dogs


Advantage Multi for Cats

Heartgard Plus for Dogs

by Merial

4.9 29

* Required Fields


This product requires a veterinarian's prescription.

This Rx product can not be shipped to some states.



  • Kills heartworms, hookworms, roundworms, and other parasites
  • Convenient chewable made with real beef that your dog will love
  • Safe and effective; EPA and FDA approved

Given once a month for life, HEARTGARD Plus is the easiest way to help protect your pet from deadly heartworm disease.  HEARTGARD Plus also treats and controls hookworms and roundworms.


All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.

While some microfilariae may be killed by the ivermectin in HEARTGARD Plus at the recommended dose level, HEARTGARD Plus is not effective for microfilariae clearance.  A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae. Keep this and all drugs out of the reach of children.

In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

Adverse Reactions: 

In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed 1.1% of administered doses.  The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Store at controlled room temperature of 68°F - 77°F 20°C - 25°C. Excursions between 59°F - 86°F 15°C - 30°C are permitted. Protect product from light.



DOSAGE: HEARTGARD® Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6.0 mcg of ivermectin per kilogram (2.72 mcg/lb) of body weight. (See ADMINISTRATION). The recommended dosage schedule for prevention of canine heartworm disease is as follows:

Dog Weight

Chewables Per Month

Ivermectin Content

Color Coding on Foil Backing and Carton

Up to 25 lb


68 mcg


26 to 50 lb


136 mcg


51 to 100 lb


272 mcg


Give dogs over 100 lb the appropriate combination of these chewables.

HEARTGARD Chewables are recommended for use in dogs 6 weeks of age and older.

ADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to the box to protect the product from light. Because most dogs find HEARTGARD Chewables palatable, the product can be offered to the dog by hand. Alternatively, it may be added to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken to see that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

HEARTGARD Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.

When replacing another heartworm preventive in a heartworm disease preventive program, the first dose of HEARTGARD must be given within a month (30 days) after the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. For optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.


Heartgard Blue Chewables (for Dogs 1-25 lbs):
Active Ingredient Amount
Ivermectin 68 mcg
Pyrantel 57 mg


Heartgard Green Chewables (for Dogs 26-50 lbs):
Active Ingredient Amount
Ivermectin 136 mcg
Pyrantel 114 mg



Heartgard Brown Chewables (for Dogs 51-100 lbs):
Active Ingredient Amount
Ivermectin 272 mcg
Pyrantel 227 mg

Additional Information

Is Rx Product Yes

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