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  • Sileo Gel for Dogs  (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe Sileo Gel for Dogs  (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe

Sileo Gel for Dogs (Dexmedetomidine Oromucosal) 0.09 mg/ml, 3 ml syringe

by Zoetis

5 4

This product requires a veterinarian's prescription.

This Rx product can not be shipped to some states.


SILEO helps to alleviate signs of noise aversion by:

  • Calming without sedating, so that the dog remains fully functional to interact normally with the family
  • Reducing the dog’s suffering and distress and, subsequently, the pet owner’s stress, helping to preserve the human-animal bond
  • Easy to Administer
  • Works on its own without any other treatments or training

Relief for Your Patients

  • Quick onset of action
  • Supports early intervention for optimal effect on the quality of life of the dog8

Confidence for You and Your Team

  • Proven to be safe and effective in a randomized, placebo-controlled clinical trial
  • An easy treatment for a challenging condition

Frequency of Common Noise Aversion Behaviors Experienced by Pet Owners:



Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handle gel-dosing syringes with caution to avoid direct exposure to skin, eyes or mouth. SILEO has not been evaluated for aversion behaviors to thunderstorms. 

Possible Side Effects:

Please read cautions: No serious adverse reactions are attributed to the administration of dexmedetomidine oromucosal gel in dogs.


Human Safety: Not for human use. Keep out of reach of children. *Avoid administering the product if pregnant, as exposure may induce uterine contractions and/or decrease fetal blood pressure. Appropriate precautions should be taken while handling and using filled syringes. Impermeable disposable gloves should be worn when handling the syringe, administering SILEO, or when coming in contact with the dog’s mouth after application.


Store unopened and opened syringes in the original package at controlled room temperature 20-25°C (68-77°F) with excursions permitted to 15-30°C (59-86°F). Use syringe contents within 2 weeks after opening the syringe.




It is important to follow your veterinarian's prescription instructions for your pet.

SILEO is administered onto the oral mucosa between the dog’s cheek and gum at the dose of 125 mcg/m2. The gel is absorbed through the oral mucosa and therefore it
should NOT be swallowed. If the gel is swallowed, the product may not be effective. If the gel is swallowed, do not repeat the dose for at least two hours.
The following table provides the acceptable dosage for each weight range. Each dot (●) represents 0.25 mL of SILEO.
Each ml contains the equivalent to 0.1mg dexmedetomidine hydrochloride.
Dosage by body weight :
Bodyweight (lb)  /  Number of dots
4.4-12.1                       1 ●
12.2-26.5                     2 ●●
26.6-44.0                     3 ●●●
44.1-63.9                     4 ●●●●
64.0-86.0                     5 ●●●●●
86.1-110.2                   6 ●●●●●●
110.3-137.8                 7 ●●●●●●●
137.9-166.4                 8 ●●●●●●●●
166.5-196.2                 9 ●●●●●●●●●
196.3-220.5              10 ●●●●●●●●●●
* If the dose is more than 6 dots, divide the dose between both sides of the mouth
The first dose can be administered:
Approximately 30 to 60 minutes before the fear and/or anxiety eliciting noise stimulus
Or immediately after the dog shows first signs of anxiety or fear related to noise
Or when the owner detects a typical noise stimulus (e.g., fireworks) eliciting anxiety or fear in the dog
If noise lasts greater than 2–3 hours and the dog’s signs of fear and/or anxiety reappear, another dose may be given:
At minimum intervals of 2 hours between doses
Up to five doses can be given during one noise event


Dexmedetomidine Oromucosal 0.09 mg/ml, 3 ml syringe

Additional Information

Is Rx Product Yes

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