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  • Uniprim Uniprim

Uniprim Powder for Horses

by Neogen

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This product requires a veterinarian's prescription.

This Rx product can not be shipped to some states.



  • Palatable top-dressed broad-spectrum antibiotic for use in horses that is active against a wide spectrum of bacterial pathogens, both gram-negative and gram-positive, including Escherichia, Streptococcus, Proteus, Salmonella, Pasteurella, Shigella and Haemophilus.
  • Indicated where potent systemic antibacterial action is required against abscesses, wound infections, urogenital infections, strangles and respiratory tract infections.


Trimethoprim/sulfadiazine is indicated in horses where potent systemic antibacterial action against sensitive organisms is required. Trimethoprim/sulfadiazine is indicated where control of bacterial infections is required during treatment of:

Acute Strangles, Respiratory Tract Infections, Acute Urogenital Infections, Wound Infections and Abscesses

Trimethoprim/sulfadiazine is well tolerated by foals.


Trimethoprim/sulfadiazine should not be used in horses showing marked liver parenchymal damage, blood dyscrasias, or in those with a history of sulfonamide sensitivity.


Do not use in horses intended for human consumption.



Water should be readily available to horses receiving sulfonamide therapy.


There is a risk for antibiotic-associated diarrhea or colic. There is a risk for injection site discomfort, swelling, and tissue damage with intramuscular (IM) or under the skin (SQ) injections. High doses have been reported to cause altered bacterial flora resulting in large intestinal inflammation, abnormal stool, reduced appetite, weight loss, and inactivity. All antibiotics have the potential to cause an overgrowth of nonsusceptible organisms. All injectable medications have the potential to cause an immediate allergic or anaphylactic reaction. Affected animals may have a swelling, hives, changes in respiration, and display signs of agitation. This can be a severe and life threatening reaction; immediate treatment with epinephrine is often required.
There is a risk for a short period of pruritus (itchiness) after IV injections.
This medication can affect the circulating blood cells causing an anemia (low red blood cells), a thrombocytopenia (low platelets), or a leukopenia (low white blood cells).
Notify your veterinarian immediately if your horse experiences any adverse reactions to this medication


The effect of trimethoprim/sulfadiazine on pregnancy has not been determined. Studies to date show that there is no detrimental effect on stallion spermatogenesis with or following the recommended dose of trimethoprim/sulfadiazine.


Store at or below 25°C (77°F)



Follow your Veterinarian's presciption instructions for your pet.

The recommended dose is 3.75 g trimethoprim/sulfadiazine per 110 lbs 50 kg body weight per day. Administer trimethoprim/sulfadiazine Powder orally once a day in a small amount of palatable feed.

The usual course of treatment is a single, daily dose for five to seven days.

Continue acute infection therapy for two or three days after clinical signs have subsided.

If no improvement of acute infections is seen in three to five days, re-evaluate diagnosis.

Trimethoprim/sulfadiazine may be used alone or in conjunction with intravenous dosing. Following treatment with trimethoprim/sulfadiazine 48% injection, therapy can be maintained using oral powder.

A complete blood count should be done periodically in patients receiving trimethoprim/sulfadiazine for prolonged periods. If significant reduction in the count of any formed blood element is noted, treatment with trimethoprim/sulfadiazine should be discontinued.

Dose Instructions: One 37.5 g packet is sufficient to treat 1100 lbs (500 kg) of body weight. For the 1125 g packets and 12 kg boxes, a level, loose-filled, 67 cc scoop contains 37.5 g, sufficient to treat 1100 lbs (500 kg) of body weight. For the 200 g400 g, and 1200 g jars, and 2000 g pail, two level, loose-filled, 32 cc scoops contain 37.5 g, sufficient to treat 1100 lbs (500 kg) of body weight. Since product contents may settle, gentle agitation during scooping is recommended.



UNIPRIM Powder contains 67 mg trimethoprim and 333 mg sulfadiazine per gram.

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