- Promotes healing and decrease inflammation caused by skin ulcers (especially in Shelties and Collies)
- Increases blood flow to areas not getting enough blood (ie. improve microcirculation)
- Treats allergic reactions caused by physical contact with an allergen (ex. contact dermatitis)
- for Dogs, Cats and Horses
If your pet shows signs of agitation, restlessness, or a rapid heartbeat while taking pentoxifylline, contact your veterinarian immediately
Because pentoxifylline may interact with other drugs, contact your veterinarian before giving any other medications.
Warfarin use with pentoxifylline may result in an increased risk of bleeding
Concomitant use of other methylxanthines theophylline may lead to increased blood levels and toxicity of one of the methylxanthines.
Patients should be monitored for efficacy of treatment. Because pentoxifylline is a methylxanthine, dogs and cats in particular should be monitored for such adverse reactions as central nervous system or cardiovascular stimulation.
Safety in Pregnant pets is unknown and should not be used in nursing mothers.
Use with caution with Pet's with the following conditions:
Pre existing seizure disorders, bleeding disorders, GI ulcers, liver or kidney insufficiency or if pet has had a past allergic reaction to pentoxifylline, theophylline or other xanthines including aminophylline or caffeine.
Possible Side Effects:
Medically and scientifically documentation has stated that this medication does affect the GI tract, vomiting and diarrhea has been warranted by oral dosage. Due to its anti-coagulate effect on the bloodstream, retinal or cerebral bleed can occur. If this medication is prescribed, be vigilant and watch for signs that may be a health concern for your pet.
Dosage and Administration:
Follow your Veterinarian's prescription dosage and instructions
For dogs, the dose of pentoxifylline as adjunctive therapy for ulcerative dermatosis is 400 mg PO sid or every other day if vomiting is a problem. For adjunctive treatment of dermatomyositis, the dose is 10 mg/kg by mouth once a day or every other day. Two to 3 months of therapy may be needed to see improvement. 9 For adjunctive treatment of ear margin seborrhea, the recommended dose of pentoxifylline is 400 mg/day PO unless the dog weighs less than 10 kg in which case 200 mg/day is administered.
In horses, a dose of 8.5 mg/kg PO bid is recommended for reducing the cytokine effects in endotoxemia. For the treatment of navicular disease, 6 g/day PO for 6 weeks should be used.3
Pentoxifylline should be given with a small amount of food or a treat to lessen gastrointestinal upset.
Give your pet only the dose of pentoxifylline recommended by your veterinarian