Torsemide 5 mg per Tablet

Benefits:

• More powerful diuretic than furosemide
• can be used in cats and dogs

Precautions:

Keep out of reach of children and pets.

Contact veterinarian if clinical signs of water or electrolyte imbalance occur. Signs such as excessive thirst, lethargy, restlessness, increased urination, GI distress or rapid heart rate may indicate electrolyte or water balance problems.

Possible Side Effects:

Patients should be monitored for dehydration. Animals with normal food and water intake are much less likely to develop water and electrolyte imbalances than those that do not.

Other potential adverse effects include gastrointestinal disturbances, hematologic effects (anemia, leukopenia), weakness, and restlessness. Torsemide, unlike furosemide, apparently only rarely causes significant ototoxic effects in humans; very high doses in laboratory animals have induced ototoxicity.

Possible Drug Interactions:

Drug Interactions

The following drug interactions have either been reported or are theoretical in humans or animals receiving torsemide and may be of significance in veterinary patients:

■ ACE INHIBITORS (e.g., enalapril, benazepril): Increased risks for hypotension, particularly in patients who are volume or sodium depleted secondary to diuretics

■ AMINOGLYCOSIDES (gentamicin, amikacin, etc.): Other diuretics have been associated with increasing the ototoxic or nephrotoxic risks of aminoglycosides. It is unknown if torsemide can also have these effects and if so, what the clinical significance may be.

■ AMPHOTERICIN B: Loop diuretics may increase the risk for nephrotoxicity development

■ DIGOXIN: Can increase the area under the curve of torsemide by 50%, but is unlikely to be of significance clinically; torsemide-induced hypokalemia may increase the potential for digoxin toxicity

■ LITHIUM: Torsemide may reduce lithium clearance

■ NSAIDs: Some NSAIDs may reduce the natriuretic effects of torsemide

■ PROBENECID: Can reduce the diuretic efficacy of torsemide

■ SALICYLATES: Torsemide can reduce the excretion of salicylates

Laboratory Considerations

■ Torsemide can affect serum electrolytes, glucose, uric acid, and BUN concentrations.

It is important to follow your Veterinarian's prescription instructions for your pet

Torsemide